Faa use of sedating antihistamines
Antihistamines have no role in the acute management of anaphylaxis.
Other conditions may cause similar symptoms, but they can be distinguished from allergic rhinitis by allergy testing to confirm positive allergen-specific Ig E to specific triggers.
Desloratadine and fexofenadine are registered for use in infants six months and older, while loratadine and cetirizine can be used from 12 months of age.
Some antihistamines are used for their antinausea or sedative Loratadine is metabolised in the liver, while cetirizine, desloratadine and fexofenadine are not metabolised extensively.
The patient can therefore choose the particular drug that they find works best, or the formulation (tablet size) that suits them.
For paediatric suspensions, the choice may be determined by a preferred flavour.
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There is now little role for sedating antihistamines in allergic conditions.