Rebecca Herbst originally auditioned for the role of Sarah Webber.
Although she did not get the part, General Hospital created the role of Sarah's sister, Elizabeth for Herbst to play, and she debuted on August 1, 1997.
Soap Opera Weekly stated in November 1998: "After the initial shock of the attack wore off, and with support – mostly from Lucky – the best parts of the 'old' Liz resurfaced: her spirit, her determination, her innate smarts.
But for the first time, Liz also showed herself as a person of untapped virtue and considerable substance." "Ever since her trauma, Liz has matured more and my character has evolved as a result.
In May 2011, it was confirmed that Herbst would take medical leave, due to viral meningitis.
The role was temporarily portrayed by actress Martha Madison, known for her role as Belle Black on Days of our Lives, from June 8–20, 2011, In February 2016, Daytime Confidential reported that contract negotiations between Herbst and the show had reached a stalemate, also that Days of Our Lives has expressed interest in hiring Herbst possibly as the potential replacement for Kate Mansi, who had vacated the role of Abigail Deveraux.